4-羟基-2-甲基氧苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF, RT, overnight 2: 1 h / 235 - 245 °C 3: 5 N aq. NaOH / methanol / Heating View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
sodium carbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate
参考文献
Mavunkel, Babu J.; Perumattam, John J.; Tan, Xuefei; Luedtke, Gregory R.; Lu, Qing; Lim, Don; Kizer, Darin; Dugar, Sundeep; Chakravarty, Sarvajit; Xu, Yong-jin; Jung, Joon; Liclican, Albert; Levy, Daniel E.; Tabora, Jocelyn
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1059 - 1062
反应条件
H2; palladium monocarbide in ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5665719 A1, 1997 ;
US 5665719 A
反应条件
1.1: 33 percent / pyridine / CH2Cl2 / 48 h / 20 °C
2.1: K2CO3 / dimethylformamide
2.2: 76 percent / dimethylformamide / 1.5 h / 35 °C
3.1: 46 percent / K2CO3 / methanol / 3 h / 20 °C
View Scheme
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
反应条件
1: 96 percent / NaH / dimethylformamide
2: 86 percent / H2, AcOH / Pd/C / methanol
View Scheme
参考文献
Kuo, Michelle S.; Bock, Mark G.; Freidinger, Roger M.; Guidotti, Maribeth T.; Lis, Edward V.; Pawluczyk, Joseph M.; Perlow, Debra S.; Pettibone, Douglas J.; Quigley, Amy G.; Reiss, Duane R.; Williams, Peter D.; Woyden, Carla J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3081 - 3086
反应条件
potassium carbonate in methanol
T=20°C; 3 h;
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
反应条件
in methanol
T=20°C; 12 h;
参考文献
Wu, Shuhsien; Zhao, Zhendong; Okada, Yoshiharu; Watanabe, Yoshiyuki; Takahata, Toshiyuki; Inoue, Toshio; Otsubo, Eiji; Wang, Jing; Lu, Yanju; Nomura, Masato
Asian Journal of Chemistry, 2014 , vol. 26, # 3 art. no. 15485, p. 702 - 708
反应条件
1: SOCl2
2: NEt3, DMAP / dimethylformamide
3: 1.) NaH / 1.) DMF
4: DOWEX 50X2 / methanol
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
1: 1.) NaH / 1.) DMF
2: DOWEX 50X2 / methanol
View Scheme
参考文献
Patek; Lebl
Tetrahedron Letters, 1991 , vol. 32, # 31 p. 3891 - 3894
反应条件
1.1: K2CO3 / dimethylformamide
1.2: 76 percent / dimethylformamide / 1.5 h / 35 °C
2.1: 46 percent / K2CO3 / methanol / 3 h / 20 °C
View Scheme
参考文献
Legrand, Sacha; Nordlander, Goeran; Nordenhem, Henrik; Borg-Karlson, Anna-Karin; Unelius, C. Rikard
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 7 p. 829 - 835
