1-甲基-5-硝基尿嘧啶合成路线 （共 17 条）
反应条件
1: aq. NaOH solution; Na2S2O4 2: 210 °C View Scheme
参考文献
Bredereck; Edenhofer
Chemische Berichte, 1955 , vol. 88, p. 1306,1309
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Corvas International, Inc.
Patent: US6011158 A1, 2000 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=80°C; 24 h; Heating / reflux;
参考文献
Corvas International, Inc.
Patent: US6342504 B1, 2002 ;
Location in patent: Page column 64 ;
US 6342504 B1
反应条件
tetra(n-butyl)ammonium hydroxide in methanol; acetonitrile
T=40°C; 72 h;
参考文献
Pecorari; Vampa; Albasini; Rinaldi; Melegari; Costi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 4 p. 311 - 318
反应条件
nitric acid
0.5 h; Ambient temperature;
参考文献
Giziewicz, Jerzy; Wnuk, Stanislaw F.; Robins, Morris J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2149 - 2151
反应条件
acetic anhydride; copper(II) nitrate
4 h; Ambient temperature;
参考文献
Giziewicz, Jerzy; Wnuk, Stanislaw F.; Robins, Morris J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2149 - 2151
反应条件
acetic anhydride; copper(II) nitrate
4 h; Ambient temperature;
参考文献
Giziewicz, Jerzy; Wnuk, Stanislaw F.; Robins, Morris J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2149 - 2151
反应条件
sulfuric acid
0.5 h; Ambient temperature;
参考文献
Giziewicz, Jerzy; Wnuk, Stanislaw F.; Robins, Morris J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2149 - 2151
反应条件
in N,N-dimethyl-formamide
5 h; Heating;
参考文献
Kuz'menko, I. I.; Bobkov, V. N.; Zvolinskaya, T. V.
J. Gen. Chem. USSR (Engl. Transl.), 1989 , vol. 59, # 8.1 p. 1751 - 1755,1557 - 1561
反应条件
1: 10 percent / aq. H2SO4 / 0.5 h / Ambient temperature
2: 85 percent / fuming HNO3 / 0.5 h / Ambient temperature
View Scheme
参考文献
Giziewicz, Jerzy; Wnuk, Stanislaw F.; Robins, Morris J.
Journal of Organic Chemistry, 1999 , vol. 64, # 6 p. 2149 - 2151
