acetic acid; chloroacetic acid 18 h; Heating;

1: 87 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating 2: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h 3: NH3(g) / methanol / 18 h / Ambient temperature View Scheme