4-氯-8-羟基-2-甲基喹啉合成路线 （共 14 条）
反应条件
boron tribromide 2 h; Heating;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C 2: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating 3: 70.4 percent / boron tribromide / 2 h / Heating View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 99.8 percent / AcOH / benzene / 8 h / Heating 2: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C 3: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating 4: 70.4 percent / boron tribromide / 2 h / Heating View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating 2: 70.4 percent / boron tribromide / 2 h / Heating View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
in 1,4-dioxane 6 h; Heating;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6083959 A1, 2000 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6008229 A1, 1999 ;
反应条件
sodium methylate in methanol
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US5994368 A1, 1999 ;
反应条件
in methanol 5 h; Heating;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Hatori, Chie; Aramori, Ichiro; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2853 - 2863
反应条件
1: ethanol With sodium hydride 0.25 h; cooling; 2: 4-chloro-8-hydroxy-2-methylquinoline in various solvent(s) T=100°C; 23 h;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Hatori, Chie; Aramori, Ichiro; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2853 - 2863
