3alpha,7alpha-二乙酰氧基-12-氧代-5beta-胆烷-24-酸甲酯合成路线 （共 5 条）
反应条件
1: methanol. KOH-solution View Scheme
参考文献
Helvetica Chimica Acta, , vol. 30, p. 1542,1552
反应条件
1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 2: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale View Scheme
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
Patent: WO2014/20024 A1, 2014 ;
反应条件
sodium ethanolate; hydrazine hydrate T=160°C;
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
Patent: WO2014/20024 A1, 2014 ;
Location in patent: Page/Page column 5; 8; 9 ;
反应条件
1.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 2.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 3.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 3.2: 30 °C / |Large scale 3.3: |Large scale 4.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 4.2: 2 h / |Reflux; |Large scale View Scheme
反应条件
1.1: hydrazine hydrate; potassium hydroxide / 1,2-bis-(2-hydroxyethoxy)-ethane / 4 h / 120 - 210 °C / |Large scale 2.1: sulfuric acid; sodium bromide; Sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / |Large scale 3.1: sodium / Sec-butyl alcohol / 0.5 h / |Reflux; |Large scale 3.2: 30 °C / |Large scale 3.3: |Large scale 4.1: water; phosphoric acid / Sec-butyl alcohol / 70 °C / |Large scale 4.2: 2 h / |Reflux; |Large scale 5.1: water; sodium hydroxide / 2 h / 97 °C / |Large scale View Scheme
参考文献
ERREGIERRE S.P.A.; FERRARI, Massimo; ZINETTI, Fabrizio
Patent: WO2014/20024 A1, 2014 ;
