1H-苯并三唑-1-甲醇合成路线 （共 47 条）
反应条件
1: 96 percent / ethanol / 5 h / Ambient temperature
2: 80 percent / 0.5 h / 100 °C
View Scheme
参考文献
Burckhalter et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 3868
反应条件
1: α-methyltetralone With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: 1-Hydroxymethyl-1H-benzotriazole in tetrahydrofuran
T=-78°C; 2 h;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Organic Letters, 2007 , vol. 9, # 6 p. 1165 - 1167
反应条件
in ethanol
T=20°C; 24.0833 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; CAO, Sheldon X.; ICHIKAWA, Takashi; KIRYANOV, Andre, A.; MCBRIDE, Christopher; NATALA, Srinivasa, Reddy; KALDOR, Stephen, W.; STAFFORD, Jeffrey, A.
Patent: WO2010/25073 A1, 2010 ;
Location in patent: Page/Page column 17-20 ;
WO 2010/025073 A1
参考文献
Milata; Kada; Zalibera; Belicova
Bollettino Chimico Farmaceutico, 2001 , vol. 140, # 4 p. 215 - 220
反应条件
1: 60 percent / acetic acid / 0.25 h / Heating
2: 78 percent / methanol; H2O / 72 h / Heating
View Scheme
参考文献
Katritzky, Alan R.; Lan, Xiangfu; Lam, Jamshed N.
Synthesis, 1990 , p. 341 - 346
反应条件
1: phenyl-acetic acid methyl ester With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: 1-Hydroxymethyl-1H-benzotriazole in tetrahydrofuran
T=-78°C; 2 h;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Organic Letters, 2007 , vol. 9, # 6 p. 1165 - 1167
反应条件
in benzene-d6
Equilibrium constant;
参考文献
Katritzky, Alan R.; Perumal, Subbu; Savage, G. Paul
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1990 , # 6 p. 921 - 924
