CYCLO(-PRO-VAL)合成路线 （共 19 条）
反应条件
toluene-4-sulfonic acid in dichloromethane
T=20°C; 20 h;
参考文献
Hendea, Daniela; Laschat, Sabine; Baro, Angelika; Frey, Wolfgang
Helvetica Chimica Acta, 2006 , vol. 89, # 9 p. 1894 - 1909
反应条件
in water
T=130°C; 4 h;
参考文献
Thajudeen, Habeebullah; Park, Kyungseok; Moon, Surk-Sik; Hong, In Seok
Tetrahedron Letters, 2010 , vol. 51, # 9 p. 1303 - 1305
反应条件
1: N,N-dicyclohexylcarbodiimide / CH2Cl2
2: HCl / CH2Cl2 / 0 °C
3: 1.) aq. sodium bicarbonate / 1.) room temperature; 2.) reflux, methanol, 24 h
View Scheme
参考文献
Smith, Grant Gill; Evans, Robert C.; Baum, Rocky
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7327 - 7332
反应条件
1: N,N-dicyclohexylcarbodiimide / CH2Cl2
2: HCl / CH2Cl2 / 0 °C
3: 1.) aq. sodium bicarbonate / 1.) room temperature; 2.) reflux, methanol, 24 h
View Scheme
参考文献
Smith, Grant Gill; Evans, Robert C.; Baum, Rocky
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7327 - 7332
反应条件
T=110°C; P=12 Torr; 3 h;
参考文献
Edwards, Oliver E.; Rank, Werner
Canadian Journal of Chemistry, 1990 , vol. 68, # 9 p. 1425 - 1436
反应条件
sodium hydrogencarbonate
1.) room temperature; 2.) reflux, methanol, 24 h; Multistep reaction;
参考文献
Smith, Grant Gill; Evans, Robert C.; Baum, Rocky
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7327 - 7332
反应条件
1: With benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane
T=20°C; 24 h;
2: With triethylamine; trifluoroacetic acid in methanol
12 h; Heating;
参考文献
Hendea, Daniela; Laschat, Sabine; Baro, Angelika; Frey, Wolfgang
Helvetica Chimica Acta, 2006 , vol. 89, # 9 p. 1894 - 1909
反应条件
1: hydrogenolysis / 30percent Pd on charcoal / ethanol
2: 41 percent / 3 h / 110 °C / 12 Torr
View Scheme
参考文献
Edwards, Oliver E.; Rank, Werner
Canadian Journal of Chemistry, 1990 , vol. 68, # 9 p. 1425 - 1436
反应条件
hydrogenchloride in ethyl acetate
T=20°C;
参考文献
Diez-Torrubia, Alberto; Garcia-Aparicio, Carlos; Cabrera, Silvia; De Meester, Ingrid; Balzarini, Jan; Camarasa, Maria-Jose; Velazquez, Sonsoles
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 559 - 572
反应条件
piperidine in N,N-dimethyl-formamide
T=20°C; 0.0833333 h;
参考文献
Diez-Torrubia, Alberto; Garcia-Aparicio, Carlos; Cabrera, Silvia; De Meester, Ingrid; Balzarini, Jan; Camarasa, Maria-Jose; Velazquez, Sonsoles
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 559 - 572
