CYCLO(-PRO-VAL)合成路线 （共 19 条）
反应条件
1.1: LDA / tetrahydrofuran / 4 h / -78 °C
1.2: tetrahydrofuran / 16 h / -78 °C
2.1: 100 percent / TsOH*H2O / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Hendea, Daniela; Laschat, Sabine; Baro, Angelika; Frey, Wolfgang
Helvetica Chimica Acta, 2006 , vol. 89, # 9 p. 1894 - 1909
反应条件
1.1: 77 percent / CH2Cl2 / 24 h / Heating
2.1: LDA / tetrahydrofuran / 4 h / -78 °C
2.2: tetrahydrofuran / 16 h / -78 °C
3.1: 100 percent / TsOH*H2O / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Hendea, Daniela; Laschat, Sabine; Baro, Angelika; Frey, Wolfgang
Helvetica Chimica Acta, 2006 , vol. 89, # 9 p. 1894 - 1909
反应条件
1: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenztriazole
2: 1.) 4M HCl; 2.) N-methylmorpholine / 2.) 2M AcOH / 1.) dioxane, r.t., 30 min; 2.) 2-butanol, reflux
View Scheme
参考文献
Suzuki; Sasaki; Endo; Mihara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 233 - 237
反应条件
1: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenztriazole
2: 1.) 4M HCl; 2.) N-methylmorpholine / 2.) 2M AcOH / 1.) dioxane, r.t., 30 min; 2.) 2-butanol, reflux
View Scheme
参考文献
Suzuki; Sasaki; Endo; Mihara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 233 - 237
参考文献
Wang, De-Xin; Liang, Ming-Tao; Tian, Gui-Jie; Lin, Hao; Liu, Hong-Qiang
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 865 - 867
反应条件
palladium 10 on activated carbon; hydrogen in methanol
参考文献
Diez-Torrubia, Alberto; Garcia-Aparicio, Carlos; Cabrera, Silvia; De Meester, Ingrid; Balzarini, Jan; Camarasa, Maria-Jose; Velazquez, Sonsoles
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 559 - 572
反应条件
palladium 10 on activated carbon; hydrogen in methanol
参考文献
Diez-Torrubia, Alberto; Garcia-Aparicio, Carlos; Cabrera, Silvia; De Meester, Ingrid; Balzarini, Jan; Camarasa, Maria-Jose; Velazquez, Sonsoles
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 559 - 572
反应条件
palladium 10 on activated carbon; hydrogen in methanol
参考文献
Diez-Torrubia, Alberto; Cabrera, Silvia; De Castro, Sonia; Garcia-Aparicio, Carlos; Mulder, Gwenn; De Meester, Ingrid; Camarasa, Maria-Jose; Balzarini, Jan; Velazquez, Sonsoles
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 456 - 468
反应条件
chloroform
Behandlung des Reaktionsprodukts mit aethanol.NH3;
参考文献
Butenandt et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1951 , vol. 288, p. 279,283
