4-甲基伞形酮 2,3,4,6-O-四乙酰基-alpha-D-吡喃甘露糖苷合成路线 （共 5 条）
反应条件
boron trifluoride dimethyl etherate in dichloromethane T=20°C; Inert atmosphere;
参考文献
METASIGNAL THERAPEUTICS INC.; SUPURAN, Claudiu; DEDHAR, Shoukat; CARTA, Fabrizio; WINUM, Jean-Yves; MCDONALD, Paul C; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; CNRS - DIRE
Patent: WO2012/70024 A1, 2012 ;
Location in patent: Page/Page column 22-29 ;
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 58 h;
参考文献
Park, Sungjin; Shin, Injae
Organic Letters, 2007 , vol. 9, # 4 p. 619 - 622
反应条件
1.1: morpholine / dichloromethane / 20 °C / Inert atmosphere 2.1: dichloromethane / 1 h / 0 °C / Inert atmosphere 2.2: 0.5 h / 0 °C / Inert atmosphere 3.1: boron trifluoride dimethyl etherate / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
METASIGNAL THERAPEUTICS INC.; SUPURAN, Claudiu; DEDHAR, Shoukat; CARTA, Fabrizio; WINUM, Jean-Yves; MCDONALD, Paul C; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; CNRS - DIRE
Patent: WO2012/70024 A1, 2012 ;
反应条件
1.1: dichloromethane / 1 h / 0 °C / Inert atmosphere 1.2: 0.5 h / 0 °C / Inert atmosphere 2.1: boron trifluoride dimethyl etherate / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
METASIGNAL THERAPEUTICS INC.; SUPURAN, Claudiu; DEDHAR, Shoukat; CARTA, Fabrizio; WINUM, Jean-Yves; MCDONALD, Paul C; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; CNRS - DIRE
Patent: WO2012/70024 A1, 2012 ;
反应条件
methanol; sodium methylate T=20°C; 0.5 h;
参考文献
Touisni, Nadia; Maresca, Alfonso; McDonald, Paul C.; Lou, Yuanmei; Scozzafava, Andrea; Dedhar, Shoukat; Winum, Jean-Yves; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8271 - 8277
