3-氯-1-[4-(2-甲基-2-丙基)苯基]-1-丙酮合成路线 （共 5 条）
反应条件
aluminium trichloride in dichloromethane 4 h; Ambient temperature;
参考文献
Boberg, Friedrich; Deters, Karin; Schulz, Juergen; Torges, Karl-Franz
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 91, # 1-4 p. 69 - 80
反应条件
sulfuric acid T=95°C; 3 h;
参考文献
JANSSEN PHARMACEUTICA NV; CARRUTHERS, Nicholas, I.; SHIREMAN, Brock, T.; TRAN, Vi, T.; WONG, Victoria, D.; JABLONOWSKI, Jill, A.; CHAI, Wenying
Patent: WO2010/59393 A1, 2010 ;
Location in patent: Page/Page column 125 ;
WO 2010/059393 A1
反应条件
1: sulfuric acid / dichloromethane / 2 h / 90 °C / |Large scale
2: ammonia
3: water; methanol / 1 h / 65 °C / |Large scale
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
5: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
反应条件
1.1: sulfuric acid / dichloromethane / 2 h / 90 °C
2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 20 °C
3.2: 0 - 20 °C
4.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr
5.1: (R)-N-acetylleucine / methanol / 1 h / 65 °C
View Scheme
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; FRORMANN, Sven
Patent: WO2012/62463 A1, 2012 ;
反应条件
1.1: sulfuric acid / dichloromethane / 2 h / 90 °C
2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 20 °C
3.2: 0 - 20 °C
4.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
