3,4-(亚甲基二氧)苯乙酸合成路线 （共 57 条）
反应条件
1: With potassium hydroxide; water in methanol 3 h; Heating / reflux; 2: With hydrogenchloride in water pH=1;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: WO2008/144602 A1, 2008 ;
Location in patent: Page/Page column 64; 66 ;
WO 2008/144602 A1
反应条件
1: With hydrazine hydrate; potassium hydroxide T=0 - 110°C; 2: With hydrogenchloride T=0°C; pH=3 - 4;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop
Patent: WO2010/127855 A1, 2010 ;
Location in patent: Page/Page column 114; 115 ;
反应条件
orthophosphorus acid; methanesulfonic acid; sodium iodide in water T=40°C; 48 h; Inert atmosphere;
参考文献
Milne, Jacqueline E.; Storz, Thomas; Colyer, John T.; Thiel, Oliver R.; Dilmeghani Seran, Mina; Larsen, Robert D.; Murry, Jerry A.
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9519 - 9524
反应条件
sodium hydroxide in tetrahydrofuran 1.5 h; Ambient temperature;
参考文献
Schuda, Paul Francis; Price, William A.
Journal of Organic Chemistry, 1987 , vol. 52, # 10 p. 1972 - 1979
反应条件
jones reagent in acetone T=0°C;
参考文献
Barreiro, Eliazer J.; Costa, Paulo R. R.; Coelho, Fernando A. S.; Farias, Florence M. C. de
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2301 - 2332
反应条件
hydrogen bromide T=100°C; 0.166667 h;
参考文献
McNulty, James; Das, Priyabrata
Tetrahedron, 2009 , vol. 65, # 37 p. 7794 - 7800
反应条件
potassium permanganate; tetradecyldimethylbenzylammonium chloride dihydrate; acetic acid in water; acetone; benzene 72 h; cooling;
参考文献
Moreira, Diogo Rodrigo de Magalhaes; Lima Leite, Ana Cristina; Pinheiro Ferreira, Paulo Michel; da Costa, Patricia Marcal; Costa Lotufo, Leticia Veras; de Moraes, Manoel Odorico; Brondani, Dalci Jose; do O Pessoa, Claudia
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 351 - 357
反应条件
sodium hydroxide in methanol Hydrolysis;
参考文献
Watson, Daniel J.; Meyers
Tetrahedron Letters, 2000 , vol. 41, # 10 p. 1519 - 1522
反应条件
potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT2 EC 3.5.5.1 in water T=30°C; pH=7.15; 14 h; Title compound not separated from byproducts;
参考文献
Mukherjee, Chandrani; Zhu, Dunming; Biehl, Edward R.; Parmar, Rajiv R.; Hua, Ling
Tetrahedron, 2006 , vol. 62, # 26 p. 6150 - 6154
反应条件
1: 97 percent / conc. H2SO4 / 3 h / Heating 2: 55 percent / CsF / dimethylformamide / 3 h / Heating 3: 97 percent / 20percent aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Cabedo; Andreu; Ramirez de Arellano; Chagraoui; Serrano; Bermejo; Protais; Cortes
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1794 - 1801
