3,4-(亚甲基二氧)苯乙酸合成路线 （共 57 条）
反应条件
1: SOCl2 / benzene / Heating
2: diethyl ether / Ambient temperature
3: 71 percent / LAH / dioxane; diethyl ether
4: 1.) SOCl2 / 1.) benzene, reflux, 2.) ether, r.t.
5: 1.) POCl3, 2.) KI / 1.) reflux, 2.) H2O
6: NaBH4 / methanol
View Scheme
参考文献
Nagarajan, K.; Talwalker, P. K.; Kulkarni, C. L.; Shah, R. K.; Shenoy, S. J.; Prabhu, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 83 - 97
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran
参考文献
LeGendre, Onica; Pecic, Stevan; Chaudhary, Sandeep; Zimmerman, Sarah M.; Fantegrossi, William E.; Harding, Wayne W.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 628 - 631
反应条件
bromine; acetic acid
T=23°C; 18 h;
参考文献
Liu, Qi; Ferreira, Eric M.; Stoltz, Brian M.
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7352 - 7358
参考文献
Sugasawa et al.
Yakugaku Zasshi, 1952 , vol. 72, p. 252
反应条件
1: 4.6 g / LiAlH4 / tetrahydrofuran / 20 °C
2: PPh3; CBr4 / acetonitrile / 20 °C
View Scheme
参考文献
Boehm; Gleason; Pendrak; Sarau; Schmidt; Foley; Kingsbury
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3333 - 3340
反应条件
1: decalin / unter Entfernen des enstehenden Wassers
2: lithium alanate; diethyl ether
View Scheme
参考文献
Dubravkova et al.
Chemicke Zvesti, 1955 , vol. 9, p. 541,543,544
Chem.Abstr., 1956 , p. 16764
反应条件
nitric acid in acetic acid
T=0 - 20°C; 0.416667 h; Inert atmosphere;
参考文献
Tietze, Lutz F.; Mueller, Michael; Duefert, Svenia-C.; Schmuck, Kianga; Schuberth, Ingrid
Chemistry - A European Journal, 2013 , vol. 19, # 5 p. 1726 - 1731
