1-(5-乙基-2-吡啶基)乙酮合成路线 （共 6 条）
反应条件
N-bromosuccinmide; water in tert-butyl alcohol T=25 - 30°C; 1 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2004/7490 A2, 2004 ;
Location in patent: Page 14 ;
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] in 1,4-dioxane; hexane T=50°C; Inert atmosphere;
参考文献
METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC; TANIS, Steven, P.; PARKER, Timothy; GADWOOD, Robert, C.; ZELLER, James, R.; ARTMAN, Gerald, D., III; LARSEN, Scott, D.
Patent: WO2012/21467 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
WO 2012/021467 A1
反应条件
1.1: n-butyllithium / toluene; tetrahydrofuran / -40 °C 1.2: 20 °C 2.1: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] / 1,4-dioxane; hexane / 50 °C / Inert atmosphere View Scheme
参考文献
METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC; TANIS, Steven, P.; PARKER, Timothy; GADWOOD, Robert, C.; ZELLER, James, R.; ARTMAN, Gerald, D., III; LARSEN, Scott, D.
Patent: WO2012/21467 A1, 2012 ;
WO 2012/021467 A1
反应条件
1: ethanolic HCl 2: sodium / Und anschliessenden Erwaermen mit wss.Salzsaeure View Scheme
参考文献
Prostenik; Filipovic
Arhiv za Kemiju, 1946 , vol. 18, p. 3,6
Chem.Abstr., 1948 , p. 3398
反应条件
sodium Und anschliessenden Erwaermen mit wss.Salzsaeure;
参考文献
Prostenik; Filipovic
Arhiv za Kemiju, 1946 , vol. 18, p. 3,6
Chem.Abstr., 1948 , p. 3398
反应条件
sodium ethanolate; hydrazine hydrate
T=180°C;
参考文献
Prostenik; Filipovic
Arhiv za Kemiju, 1946 , vol. 18, p. 3,6
Chem.Abstr., 1948 , p. 3398
