3-氯-4-甲基-6-苯基哒嗪合成路线 （共 17 条）
反应条件
1: 75 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 12 h / Heating
2: 1.) n-butyllithium, 2,2,6,6-tetramethylpiperidine / 1.) hexane, 0 degC, 30 min, THF, -70 degC, 1.5 h; 2.) -70 degC, 2 h
3: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C
4: 94 percent / phopsphorus oxychloride / 6 h / 90 °C
View Scheme
参考文献
Turck, A.; Ple, N.; Mojovic, L.; Queguiner, G.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 488 - 492
反应条件
1: 94.3 percent / hydrazine monohydrate / aq. ethanol / 2 h / Heating
2: 91.1 percent / CuCl2 / acetonitrile / 2 h / Heating
3: 96 percent / POCl3 / acetonitrile / 2.5 h / Heating
View Scheme
参考文献
Hu, Wenhui; Ralay Ranaivo, Hantamalala; Roy, Saktimayee M.; Behanna, Heather A.; Wing, Laura K.; Munoz, Lenka; Guo, Ling; Van Eldik, Linda J.; Watterson, D. Martin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 414 - 418
反应条件
1: 1.) n-butyllithium, 2,2,6,6-tetramethylpiperidine / 1.) hexane, 0 degC, 30 min, THF, -70 degC, 1.5 h; 2.) -70 degC, 2 h
2: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C
3: 94 percent / phopsphorus oxychloride / 6 h / 90 °C
View Scheme
参考文献
Turck, A.; Ple, N.; Mojovic, L.; Queguiner, G.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 488 - 492
反应条件
1: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C
2: 94 percent / phopsphorus oxychloride / 6 h / 90 °C
View Scheme
参考文献
Turck, A.; Ple, N.; Mojovic, L.; Queguiner, G.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 488 - 492
参考文献
Oppenheim
Chemische Berichte, 1901 , vol. 34, p. 4228
反应条件
sodium amide in xylene
48 h; Heating;
参考文献
Moustafa, A. H.; Kaddah, A. M.; Shams, N. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 12 p. 1084 - 1086
反应条件
in butan-1-ol
T=130°C; 60 h; Sealed vessel; Product distribution / selectivity;
参考文献
Watterson, D. Martin; Van Eldik, Linda; Hu, Wenhui
Patent: US2009/325973 A1, 2009 ;
Location in patent: Page/Page column 28 ;
