5H-[1,2,4]噻嗪o[5,6-b]吲哚-3-硫醇合成路线 （共 8 条）
反应条件
potassium carbonate 16 h; Reflux;
参考文献
ISIS INNOVATION LIMITED; CHRISTOU, Ivy; CROSS, Rebecca Lillian; GIANELLA-BORRADORI, Matteo; GREAVES, David Robert; RUSSELL, Angela Jane; WYNNE, Graham Michael
Patent: WO2013/41859 A1, 2013 ;
Location in patent: Paragraph 00157; 00158; 00159; 00160 ;
反应条件
potassium carbonate microwave irradiation;
参考文献
El Ashry, El Sayed H.; Ramadan, El Sayed; Abdel Hamid, Hamida M.; Hagar, Mohamed
Synlett, 2004 , # 4 p. 723 - 725
反应条件
1: 93 percent / AcOH / ethanol / 2.5 h / microwave irradiation 2: 87 percent / aq. K2CO3 / microwave irradiation View Scheme
参考文献
Gomha, Sobhi M.; Abdel-Aziz, Hatem A.
Journal of the Serbian Chemical Society, 2013 , vol. 78, # 8 p. 1119 - 1125
反应条件
sodium in methanol; N,N-dimethyl-formamide T=60 - 100°C; Alkylation; 15 h;
参考文献
Tomchin; Uryupov; Zhukova; Kuznetsova; Kostycheva; Smirnov
Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 3 p. 125 - 133
反应条件
potassium hydroxide in water 5 h; Reflux;
参考文献
Vasilevskii, Sergei V.; Belyakov, Pavel A.; Gazieva, Galina A.; Nelyubina, Yulia V.; Kolotyrkina, Natal'ya G.; Kravchenko, Angelina N.
Mendeleev Communications, 2010 , vol. 20, # 1 p. 47 - 49
反应条件
1: 3-mercapto-as-triazinolt;5,6-bgt;indole With potassium carbonate
microwave irradiation;
2: benzyl chloride 0.0416667 h; microwave irradiation;
参考文献
El Ashry, El Sayed H.; Ramadan, El Sayed; Abdel Hamid, Hamida M.; Hagar, Mohamed
Synlett, 2004 , # 4 p. 723 - 725
反应条件
sodium hydroxide
1 h;
参考文献
Ram
Archiv der Pharmazie, 1980 , vol. 313, # 2 p. 108 - 113
反应条件
1: 98percent hydrazine hydrate / 4 h / Heating
2: 100 percent / dimethylformamide / 1 h / Heating
View Scheme
参考文献
Ram
Archiv der Pharmazie, 1980 , vol. 313, # 2 p. 108 - 113
