11-甲基二苯并[b,f][1,4]氧氮杂卓合成路线 （共 8 条）
反应条件
iron (III) acetylacetonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether T=20°C; 0.0833333 h;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2007/47776 A1, 2007 ;
Location in patent: Page/Page column 30; 31; 32; 42; 43 ;
反应条件
trichlorophosphate in dichloromethane T=120°C; 3 h; Inert atmosphere;
参考文献
Gao, Kai; Yu, Chang-Bin; Li, Wei; Zhou, Yong-Gui; Zhang, Xumu
Chemical Communications, 2011 , vol. 47, # 27 p. 7845 - 7847
反应条件
iron (III) acetylacetonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=20°C; 0.0833333 h;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2007/47776 A1, 2007 ;
Location in patent: Page/Page column 30; 31; 32; 42; 43; 64; 65 ;
反应条件
1: 74 percent / phosphorus oxychloride / 2 h / 95 °C 2: 72 percent / Fe(acac)3 / tetrahydrofuran; diethyl ether; 1-methyl-pyrrolidin-2-one / 0.08 h / 20 °C View Scheme
参考文献
Ottesen, Lars K.; Ek, Fredrik; Olsson, Roger
Organic Letters, 2006 , vol. 8, # 9 p. 1771 - 1773
反应条件
1: 5 Pd(II)/C(eggshell); hydrogen; acetic acid / ethanol / 12 h / 3102.97 Torr 2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 3: trichlorophosphate / dichloromethane / 3 h / 120 °C / Inert atmosphere View Scheme
参考文献
Gao, Kai; Yu, Chang-Bin; Li, Wei; Zhou, Yong-Gui; Zhang, Xumu
Chemical Communications, 2011 , vol. 47, # 27 p. 7845 - 7847
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 1.2: 13 h / 20 - 50 °C / Inert atmosphere 2.1: 5 Pd(II)/C(eggshell); hydrogen; acetic acid / ethanol / 12 h / 3102.97 Torr 3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 4.1: trichlorophosphate / dichloromethane / 3 h / 120 °C / Inert atmosphere View Scheme
参考文献
Gao, Kai; Yu, Chang-Bin; Li, Wei; Zhou, Yong-Gui; Zhang, Xumu
Chemical Communications, 2011 , vol. 47, # 27 p. 7845 - 7847
反应条件
1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 180 °C / |Microwave irradiation 2: 1-methyl-pyrrolidin-2-one / 180 °C / |Microwave irradiation 3: 1-methyl-pyrrolidin-2-one / 180 °C / |Microwave irradiation View Scheme
参考文献
Lin, Yu-Chin; Li, Ni-Ching; Cherng, Yie-Jia
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 808 - 814
反应条件
1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 180 °C / |Microwave irradiation 2: 1-methyl-pyrrolidin-2-one / 180 °C / |Microwave irradiation 3: 1-methyl-pyrrolidin-2-one / 180 °C / |Microwave irradiation View Scheme
参考文献
Lin, Yu-Chin; Li, Ni-Ching; Cherng, Yie-Jia
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 808 - 814
