苯并[D]异恶唑-3-甲酸合成路线 （共 8 条）
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
1: NaH / bis-(2-methoxy-ethyl) ether 2: 70percent H2SO4 View Scheme
参考文献
Kemp,D.S.; Paul,K.G.
Journal of the American Chemical Society, 1975 , vol. 97, p. 7305 - 7312
反应条件
1: H2SO4 / toluene / Heating 2: isoamyl nitrite, NaOEt / ethanol 3: NaH / bis-(2-methoxy-ethyl) ether 4: 70percent H2SO4 View Scheme
参考文献
Hrib, Nicholas J.; Jurcak, John G.; Burgher, Kendra L.; Conway, Paul G.; Hartman, Harold B.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2308 - 2314
反应条件
1: isoamyl nitrite, NaOEt / ethanol 2: NaH / bis-(2-methoxy-ethyl) ether 3: 70percent H2SO4 View Scheme
参考文献
Hrib, Nicholas J.; Jurcak, John G.; Burgher, Kendra L.; Conway, Paul G.; Hartman, Harold B.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2308 - 2314
反应条件
sulfuric acid; triethylamine in acetone T=21°C; nitrogen isotope effect;
参考文献
Czyryca; Paneth
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7305 - 7309
参考文献
Lindemann; Cissee
Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2> 122, p. 243
反应条件
sulfuric acid; nitric acid
参考文献
Kemp,D.S.; Paul,K.G.
Journal of the American Chemical Society, 1975 , vol. 97, p. 7305 - 7312
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / tetrahydrofuran / 20 h / 20 °C
2: diethyl ether; tetrahydrofuran / 22 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/65727 A1, 2011 ;
