1: isopropyl alcohol / 2 h / 80 - 85 °C 2: sodium carbonate / water / 25 - 30 °C / pH 9.5 3: hydrogen / 5 palladium on charcoal / ethyl acetate / 18 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave 4: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere 5: hydrogen / 5 palladium on charcoal / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave View Scheme

1.1: acetone / 2 h / 40 - 45 °C 2.1: sodium hydroxide / dichloromethane; water / pH 9 - 10 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 h / 0 - 20 °C / Inert atmosphere 3.2: 0 - 5 °C 4.1: hydrogen / 5 palladium on charcoal / methanol / 2 h / 25 - 35 °C / Autoclave 4.2: 25 - 35 °C View Scheme

1.1: acetone / 2 h / 40 - 45 °C 2.1: sodium hydroxide / dichloromethane; water / pH 9 - 10 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 h / 0 - 20 °C / Inert atmosphere 3.2: 0 - 5 °C 4.1: hydrogen / 5 palladium on charcoal / methanol / 2 h / 25 - 35 °C / Autoclave 4.2: 25 - 35 °C 5.1: dichloromethane / 1.5 h / 0 - 5 °C 5.2: 0.5 h / 0 - 5 °C View Scheme

1: acetone / 2 h / 40 - 45 °C 2: sodium hydroxide / dichloromethane; water / pH 9 - 10 View Scheme