3-氧代-2,6-二氮杂双环[3.2.1]辛烷-6-羧酸苄酯合成路线 （共 5 条）
反应条件
trimethylsilylpolyphosphate in dichloromethane T=20°C; 12 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 31 ;
反应条件
hydrogenchloride in water; acetone T=20°C; 16 h;
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin
Patent: US2011/65694 A1, 2011 ;
Location in patent: Page/Page column 67 ;
反应条件
1: sodium acetate; hydroxylamine hydrochloride / aq. ethanol / 0.75 h / 20 °C 2: 1.08 g / trimethylsilylpolyphosphate / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin
Patent: US2011/65694 A1, 2011 ;
反应条件
1.1: borane-THF / tetrahydrofuran / 2.67 h / -78 - 20 °C 1.2: 0.5 h 2.1: Jone's reagent / acetone / 3 h / 0 °C 3.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2 h / 20 °C 4.1: sodium carbonate / water; acetone / 0.17 h 4.2: 16 h 5.1: hydrogenchloride / water; acetone / 16 h / 20 °C View Scheme
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin
Patent: US2011/65694 A1, 2011 ;
反应条件
1.1: Jone's reagent / acetone / 3 h / 0 °C 2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2 h / 20 °C 3.1: sodium carbonate / water; acetone / 0.17 h 3.2: 16 h 4.1: hydrogenchloride / water; acetone / 16 h / 20 °C View Scheme
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin
Patent: US2011/65694 A1, 2011 ;
