2,5,6-三氯-1H-吲哚合成路线 （共 5 条）
反应条件
1H-imidazole; trichlorophosphate in 1,2-dichloro-ethane Chlorination; 2.5 h; Heating;
参考文献
Chen, Jiong J.; Wei, Yuan; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 12 p. 2449 - 2456
反应条件
1: 82 percent / concd H2SO4 / 7 h / Heating 2: 76 percent / H2; AcOH / PtO2 / 20 h / 20 °C / 2068.65 Torr 3: 70 percent / POCl3; imidazole / 1,2-dichloro-ethane / 2.5 h / Heating View Scheme
参考文献
Chen, Jiong J.; Wei, Yuan; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 12 p. 2449 - 2456
反应条件
1: 76 percent / H2; AcOH / PtO2 / 20 h / 20 °C / 2068.65 Torr 2: 70 percent / POCl3; imidazole / 1,2-dichloro-ethane / 2.5 h / Heating View Scheme
参考文献
Chen, Jiong J.; Wei, Yuan; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 12 p. 2449 - 2456
反应条件
trichlorophosphate
T=60°C; Vilesmeier-Haack formylation; 16 h;
参考文献
Williams, John D.; Ptak, Roger G.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5773 - 5782
反应条件
nitromethane; tin(IV) chloride in dichloromethane
T=0 - 20°C; 0.75 h;
参考文献
Williams, John D.; Ptak, Roger G.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5773 - 5782
