N-苄氧羰酰基-D-苯丙氨酸合成路线 （共 27 条）
反应条件
sodium tetrahydroborate in methanol; tert-butyl alcohol T=50 - 55°C;
参考文献
Soai; Oyamada; Takase
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 8 p. 2327 - 2328
反应条件
diisobutylaluminium hydride in hexane; toluene T=-50°C;
参考文献
Misiti; Zappia
Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7359 - 7362
反应条件
CLEA-Alcalase in tert-butyl methyl ether
T=50°C; 16 h; Molecular sieve;
参考文献
Nuijens, Timo; Cusan, Claudia; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Synthesis, 2009 , # 5 p. 809 - 814
反应条件
1: N-acetyl-L-phenylalanine ethyl ester With pyridine; oxalyl dichloride in tetrahydrofuran
T=0°C; 0.5 h; Inert atmosphere;
2: With Propylene glycol in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
3: benzyl chloroformate With potassium hydrogencarbonate in water; ethyl acetate
T=0 - 20°C; 16 h;
参考文献
Koenig, Stefan G.; Vandenbossche, Charles P.; Zhao, Hang; Mousaw, Patrick; Singh, Surendra P.; Bakale, Roger P.
Organic Letters, 2009 , vol. 11, # 2 p. 433 - 436
反应条件
triethylamine in ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US3976635 A1, 1976 ;
反应条件
citrate buffer; dl-cysteine hydrochloride; papain
T=50°C; 24 h;
参考文献
Moriniere, Jean-Luc; Danree, Bernard; Guy, Alain
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 347 - 358
反应条件
4-(N,N-dimethlyamino)pyridine in neat (no solvent)
1.5 h; Milling;
参考文献
Konnert, Laure; Lamaty, Frederic; Martinez, Jean; Colacino, Evelina
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4008 - 4017
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran
0.5 h;
参考文献
Takeda; Akiyama; Nakamura; Takizawa; Mizuno; Takayanagi; Harigaya
Synthesis, 1994 , # 10 p. 1063 - 1066
反应条件
1: 4-Benzyl-2,5-dioxo-oxazolidine-3-carboxylic acid benzyl ester With ethanol; O-propargylquinine in diethyl ether
T=20°C; 0.25 h; Molecular sieve;
2: ethanol in diethyl ether
T=-60°C; 20 h; Reagent/catalyst; enantioselective reaction;
参考文献
Ishii, Yutaka; Fujimoto, Ryosuke; Mikami, Masafumi; Murakami, Satoshi; Miki, Yasushi; Furukawa, Yoshiro
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 609 - 615
反应条件
ethylenediaminetetraacetic acid; water; papain in dichloromethane
T=40°C; 24 h;
参考文献
Braun; Kuhl
Pharmazie, 1997 , vol. 52, # 3 p. 203 - 206
