N-苄氧羰酰基-D-苯丙氨酸合成路线 （共 27 条）
反应条件
1: 17 percent / phosphate buffer; α-chymotrypsin / dimethylsulfoxide / 0.5 h / 30 °C / pH 8.0
2: BF3*OEt2
View Scheme
参考文献
Salam, Sayed Mohiuddin Abdus; Kagawa, Ken-Ichi; Kawashiro, Katsuhiro
Tetrahedron Asymmetry, 2006 , vol. 17, # 1 p. 22 - 29
反应条件
sodium hydrogencarbonate; N,N-dimethyl-formamide
参考文献
Bocchi,V. et al.
Synthesis, 1979 , p. 961 - 962
反应条件
hydrogenchloride; sodium carbonate
2) CHCl3; Yield given. Multistep reaction;
参考文献
Sudharshan, Manjula; Hultin, Philip G.
Synlett, 1997 , vol. 1997, # 2 p. 171 - 172
反应条件
phosphate buffer; α-chymotrypsin in dimethyl sulfoxide
T=30°C; pH=8.0; 0.5 h;
参考文献
Salam, Sayed Mohiuddin Abdus; Kagawa, Ken-Ichi; Kawashiro, Katsuhiro
Tetrahedron Asymmetry, 2006 , vol. 17, # 1 p. 22 - 29
反应条件
in water; N,N-dimethyl-formamide
T=15°C; 12 h; porcine pancreas lipase (EC 3.1.1.3, type II crude), phosphate buffer (pH 8);
参考文献
Kawashiro, Katsuhiro; Kaiso, Kohji; Minato, Daisuke; Sugiyama, Shigeru; Hayashi, Hiromu
Tetrahedron, 1993 , vol. 49, # 21 p. 4541 - 4548
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-75°C; 0.166667 h;
参考文献
Chen, Ping; Cheng, Peter T. W.; Spergel, Steven H.; Zahler, Robert; Wang, Xuebao; Thottathil, John; Barrish, Joel C.; Polniaszek, Richard P.
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3175 - 3178
反应条件
1: DIBAH / toluene / -78 °C
2: NaH / tetrahydrofuran / 0 °C
3: I2 / acetonitrile / Ambient temperature
4: 85 percent / n-Bu3SnH / toluene / Heating
5: alkaline hydrolysis
View Scheme
参考文献
Misiti; Zappia
Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7359 - 7362
