1-吡啶-1,4-二氮杂庚烷合成路线 （共 7 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 3 h; Cooling with ice; 2: With sodium hydroxide in water
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide T=180 - 200°C; 0.666667 h; Microwave irradiation;
参考文献
Proximagen Limited; Savory, Edward Daniel; Stewart, Allson; Cartey, Allison; Brown, Giles; Simpson, Iain; Oliver, Kathryn; Patient, Lee; Higginbottom, Michael; Cole, Andrew Graham
Patent: US2013/289020 A1, 2013 ;
Location in patent: Paragraph 0376; 0377 ;
反应条件
T=120°C; 0.333333 h; Microwave irradiation;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.
Patent: WO2008/153325 A1, 2008 ;
Location in patent: Page/Page column 73 ;
反应条件
trifluoroacetic acid in dichloromethane 1 h;
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
反应条件
palladium diacetate in toluene
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1156045 A1, 2001 ;
Title/Abstract Full Text Show Details
Nippon Shinyaku Co., Ltd.
Patent: EP1243268 A1, 2002 ;
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride / 1,4-dioxane / 12 h / 20 °C / |Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / |Cooling with ice View Scheme
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
参考文献
Abbott Laboratories
Patent: WO2003/101994 A1, 2003 ;
Location in patent: Page 84 ;
WO 03/101994 A1
