2-(2-甲基-5-硝基苯基)乙酸合成路线 （共 5 条）
反应条件
thionyl chloride in N,N-dimethyl-formamide T=20°C; Esterification; 16 h;
参考文献
Sykes, Bridget M.; Hay, Michael P.; Bohinc-Herceg, Dubravka; Helsby, Nuala A.; O'Connor, Charmian J.; Denny, William A.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 10 p. 1601 - 1608
反应条件
1: 1.44 g / thionyl chloride / dimethylformamide / 16 h / 20 °C 2: H2 / Pd/C / ethanol / 3102.97 Torr View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 10 p. 1601 - 1608
反应条件
sulfuric acid; nitric acid in dichloromethane
T=-20 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; FINK, Brian; CHEN, Libing; GAVAI, Ashvinikumar; HE, Liqi; KIM, Soong-Hoon; NATION, Andrew; ZHAO, Yufen; ZHANG, Litai
Patent: WO2010/42699 A1, 2010 ;
Location in patent: Page/Page column 112-113 ;
WO 2010/042699 A1
反应条件
methanol; potassium hydroxide; water
14 h; Heating / reflux;
参考文献
IRM LLC
Patent: WO2008/51757 A1, 2008 ;
Location in patent: Page/Page column 33; 34 ;
WO 2008/051757 A1
反应条件
sulfuric acid; nitric acid
T=-10 - 20°C; Nitration; Title compound not separated from byproducts.;
参考文献
Sykes, Bridget M.; Hay, Michael P.; Bohinc-Herceg, Dubravka; Helsby, Nuala A.; O'Connor, Charmian J.; Denny, William A.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 10 p. 1601 - 1608
