5,6,7,8-四氢-3-甲基喹啉合成路线 （共 52 条）
反应条件
T=190°C; P=15200 Torr; Hydrogenation;
参考文献
v. Braun; Gmelin; Schultheiss
Chemische Berichte, 1923 , vol. 56, p. 1343
反应条件
T=190°C; P=15200 Torr; Hydrogenation;
参考文献
v. Braun; Gmelin; Schultheiss
Chemische Berichte, 1923 , vol. 56, p. 1343
反应条件
acetic anhydride; paraformaldehyde
参考文献
American Home Products Corporation
Patent: US4837329 A1, 1989 ;
Title/Abstract Full Text Show Details
John Weyth and Brother Limited
Patent: US4923991 A1, 1990 ;
反应条件
1: 22 g / acetic anhydride / 30 h / Heating
2: 22 g / hydrogen / 10percent palladium on carbon / ethanol / 1.5 h / 25 °C / 760 Torr
View Scheme
参考文献
Crossley, Roger; Shepherd, Robin G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1917 - 1920
反应条件
n-butyllithium; chloro-trimethyl-silane in tetrahydrofuran; hexane
参考文献
John Wyeth and Brother, Ltd.
Patent: US4577022 A1, 1986 ;
反应条件
n-butyllithium
1.) THF, hexane, 0.5 h, below 10 deg C 2.) 0.5 h, below 10 deg C, THF, hexane; Yield given. Multistep reaction;
参考文献
Crossley, Roger; Shepherd, Robin G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1917 - 1920
反应条件
n-butyllithium
1.) THF, hexane, below 10 deg C, 0.5 h 2.) THF, hexane, work up at ph=8; Yield given. Multistep reaction;
参考文献
Crossley, Roger; Shepherd, Robin G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1917 - 1920
反应条件
acetic anhydride; paraformaldehyde
参考文献
American Home Products Corporation
Patent: US4837329 A1, 1989 ;
Title/Abstract Full Text Show Details
John Weyth and Brother Limited
Patent: US4923991 A1, 1990 ;
反应条件
acetic anhydride
30 h; Heating;
参考文献
Crossley, Roger; Shepherd, Robin G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1917 - 1920
反应条件
sodium carbonate in water
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4738970 A1, 1988 ;
