1: 85 percent / dimethylformamide; pyridine / 2 h / Ambient temperature 2: 100 percent / H2 / 10 percent Pd/C / ethanol / Ambient temperature 3: CH2Cl2 / 40 °C View Scheme

1: 2.) HCl / 1.) Et2O, toluene, reflux, 3 h, 2.) EtOH 2: 25 percent / Et3N / dimethylformamide / 12 h / Ambient temperature 3: 85 percent / dimethylformamide; pyridine / 2 h / Ambient temperature 4: 100 percent / H2 / 10 percent Pd/C / ethanol / Ambient temperature 5: CH2Cl2 / 40 °C View Scheme