环(L-脯氨酰-L-亮氨酰)合成路线 （共 34 条）
反应条件
1: With benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane T=20°C; 24 h; 2: With triethylamine; trifluoroacetic acid in methanol 12 h; Heating;
参考文献
Hendea, Daniela; Laschat, Sabine; Baro, Angelika; Frey, Wolfgang
Helvetica Chimica Acta, 2006 , vol. 89, # 9 p. 1894 - 1909
反应条件
1: thionyl chloride / 3.5 h / Heating 2: 60 percent / CH2Cl2 / 4 h / 20 °C 3: 50 percent / cyclohexene / Pd/C / methanol / 5 h / Heating 4: 52 percent / K2CO3 / ethane-1,2-diol / 5 h / Heating View Scheme
参考文献
Jhaumeer-Laulloo; Khodabocus; Jugoo; Jheengut; Sobha
Journal of the Indian Chemical Society, 2003 , vol. 80, # 8 p. 765 - 768
反应条件
1: 60 percent / CH2Cl2 / 4 h / 20 °C 2: 50 percent / cyclohexene / Pd/C / methanol / 5 h / Heating 3: 52 percent / K2CO3 / ethane-1,2-diol / 5 h / Heating View Scheme
参考文献
Jhaumeer-Laulloo; Khodabocus; Jugoo; Jheengut; Sobha
Journal of the Indian Chemical Society, 2003 , vol. 80, # 8 p. 765 - 768
反应条件
1: 50 percent / cyclohexene / Pd/C / methanol / 5 h / Heating 2: 52 percent / K2CO3 / ethane-1,2-diol / 5 h / Heating View Scheme
参考文献
Jhaumeer-Laulloo; Khodabocus; Jugoo; Jheengut; Sobha
Journal of the Indian Chemical Society, 2003 , vol. 80, # 8 p. 765 - 768
反应条件
1: 80 percent / aq. NaOH / 2 h / 0 - 20 °C 2: 60 percent / CH2Cl2 / 4 h / 20 °C 3: 50 percent / cyclohexene / Pd/C / methanol / 5 h / Heating 4: 52 percent / K2CO3 / ethane-1,2-diol / 5 h / Heating View Scheme
参考文献
Jhaumeer-Laulloo; Khodabocus; Jugoo; Jheengut; Sobha
Journal of the Indian Chemical Society, 2003 , vol. 80, # 8 p. 765 - 768
反应条件
1: 60 percent / CH2Cl2 / 4 h / 20 °C 2: 50 percent / cyclohexene / Pd/C / methanol / 5 h / Heating 3: 52 percent / K2CO3 / ethane-1,2-diol / 5 h / Heating View Scheme
参考文献
Jhaumeer-Laulloo; Khodabocus; Jugoo; Jheengut; Sobha
Journal of the Indian Chemical Society, 2003 , vol. 80, # 8 p. 765 - 768
反应条件
1: 1) NEt3, 2) N-methylmorpholine / 1) DMF, 0 deg C, 1 h, then rt, 12 h, 2) pH 8, 24 h 2: aq. NaOH / acetone / 2 h / Ambient temperature 3: 75 percent / N-methylmorpholine, dicyclohexylcarbodiimide, HOBt / dimethylformamide / 1) pH 8, -20 deg C, 1 h, 2) rt, 48 h 4: 90 percent / aq. NaOH / dioxane; H2O / 1 h 5: H2 / 10percent Pd/C / dimethylformamide / 1 h View Scheme
参考文献
Kapurniotu, Afroditi; Voelter, Wolfgang
Liebigs Annalen der Chemie, 1992 , # 4 p. 361 - 370
反应条件
1: 75 percent / N-methylmorpholine, dicyclohexylcarbodiimide, HOBt / dimethylformamide / 1) pH 8, -20 deg C, 1 h, 2) rt, 48 h 2: 90 percent / aq. NaOH / dioxane; H2O / 1 h 3: H2 / 10percent Pd/C / dimethylformamide / 1 h View Scheme
参考文献
Kapurniotu, Afroditi; Voelter, Wolfgang
Liebigs Annalen der Chemie, 1992 , # 4 p. 361 - 370
反应条件
1: 90 percent / aq. NaOH / dioxane; H2O / 1 h 2: H2 / 10percent Pd/C / dimethylformamide / 1 h View Scheme
参考文献
Kapurniotu, Afroditi; Voelter, Wolfgang
Liebigs Annalen der Chemie, 1992 , # 4 p. 361 - 370
反应条件
1: 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU), Pd(dibenzylideneacetone)2 <Pd(dba)2>, 1,2-bisdiphenylphosphinoethane (dppe) / acetonitrile / 10 h / 25 °C 2: H2 / 10percent Pd/C / methanol / 3102.9 Torr View Scheme
参考文献
Manjunatha, Sulur G.; Rajappa, Srinivasachari
Journal of the Chemical Society, Chemical Communications, 1991 , # 6 p. 372 - 373
