4-溴-1,3-苯二甲酸二甲酯合成路线 （共 2 条）
反应条件
1: 70 percent / cuprous oxide / N,N-dimethyl-acetamide / 20 h / 165 °C 2: 75 percent / aq. KOH / ethanol / 0.5 h / Heating 3: 80 percent / conc. H2SO4 / 18 h / 20 °C View Scheme
参考文献
Kottani, Rudresha; Majjigapu, Janaki R. R.; Kurchan, Alexei; Majjigapu, Kavitha; Gustafson, Tiffany P.; Kutateladze, Andrei G.
Journal of the American Chemical Society, 2006 , vol. 128, # 46 p. 14794 - 14795
反应条件
1: Cu
2: polyphosphoric acid / tetrahydrothiophene 1,1-dioxide
3: H2SO4 / Heating
4: SO2Cl2, SiO2 / CH2Cl2
5: NaN3, polyphosphoric acid
6: aq. NaOH / ethanol
View Scheme
参考文献
Barnes,A.C. et al.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 418 - 424
