MeO2CN=NCO2Me; triphenylphosphine in tetrahydrofuran T=-78 - 20°C; Cyclization;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />Hydrogenolysis;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 96 percent / aq.HCl / Heating<br />2: 83 percent / Me₄NOH*5H₂O / acetonitrile<br />3: 100 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 83 percent / Me₄NOH*5H₂O / acetonitrile<br />2: 100 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: LDA / tetrahydrofuran / -78 &deg;C<br />1.2: tetrahydrofuran / -78 - 20 &deg;C<br />2.1: 96 percent / aq.HCl / Heating<br />3.1: 83 percent / Me₄NOH*5H₂O / acetonitrile<br />4.1: 100 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: TFA / pentane / Heating<br />2.1: LDA / tetrahydrofuran / -78 &deg;C<br />2.2: tetrahydrofuran / -78 - 20 &deg;C<br />3.1: 96 percent / aq.HCl / Heating<br />4.1: 83 percent / Me₄NOH*5H₂O / acetonitrile<br />5.1: 100 percent / H₂ / Pd/C / methanol<br /> <br /> &nbsp;