1-氯-6,6-二甲基-2-庚烯-4-炔合成路线 （共 6 条）
反应条件
thionyl chloride in hexane; N,N-dimethyl-formamide
参考文献
Sumitomo Chemical Company, Limited
Patent: US5036158 A1, 1991 ;
反应条件
boron trichloride in hexane T=20°C; Chlorination; 0.166667 h; Product distribution; Further Variations:ReagentsTemperaturesreaction time;
参考文献
AUROBINDO PHARMA LTD
Patent: WO2007/52089 A1, 2007 ;
Location in patent: Page/Page column 7 ;
参考文献
RICHTER GEDEON VEGYESZETI GYAR R.T.
Patent: EP1222160 B1, 2003 ;
反应条件
potassium hydroxide in polyethylene glycol-400 (PEG-400) T=25 - 40°C; 5 h;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2006/84826 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
1: With potassium carbonate in dimethyl sulfoxide T=25 - 60°C; 4.25 - 6.5 h; 2: With hydrogenchloride in water; ethyl acetate T=0 - 10°C; pH=1.5 - 2; 0.5 h; Product distribution / selectivity;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2006/84826 A1, 2006 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With sodium carbonate in water T=77 - 83°C; 6 - 8 h; Industry scale; 2: With hydrogenchloride in water; toluene T=20 - 25°C; pH=0.5 - 1.5; 0.333333 h; Industry scale; Product distribution / selectivity;
参考文献
Kaspi, Joseph; Arad, Oded; Friedman, Oded; Manascu, Iosef; Fizitzki, Tamir; Danon, Edna
Patent: US2006/4230 A1, 2006 ;
Location in patent: Page/Page column 6; 10-11 ;
