2-(1-甲基乙基)-苯并呋喃合成路线 （共 23 条）
反应条件
1: 95 percent / 3 h / 130 °C
2: 71 percent / bromine / CCl4 / Heating; Irradiation
3: 94 percent / toluene / 4 h / Heating
4: 97 percent / 48 percent HBr / H2O / 3 h / Heating
5: 80 percent / pyridine / CHCl3 / 3 h / Heating
6: 80 percent / triethylamine / toluene / 3 h / Heating
View Scheme
参考文献
Hercouet, A.; Corre, M. Le
Tetrahedron, 1981 , vol. 37, # 16 p. 2867 - 2874
反应条件
1: 97 percent / 48 percent HBr / H2O / 3 h / Heating
2: 80 percent / pyridine / CHCl3 / 3 h / Heating
3: 80 percent / triethylamine / toluene / 3 h / Heating
View Scheme
参考文献
Hercouet, A.; Corre, M. Le
Tetrahedron, 1981 , vol. 37, # 16 p. 2867 - 2874
反应条件
tetra-n-butylammonium tetrafluoroborate in tetrahydrofuran; water
electrolysis (mercury cathode, platinum flag anode, silver wire reference electrode, constant current 8 mA cm-2); Yield given;
参考文献
Kariv-Miller, Essie; Dedolph, Douglas F.; Ryan, Christopher M.; Mahachi, Tendai J.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1389 - 1393
反应条件
toluene-4-sulfonic acid; acetic acid
24 h; Heating;
参考文献
Katritzky, Alan R.; Lan, Xiangfu; Zhang, Zhongxing
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 2 p. 381 - 387
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, a) -78 deg C, 0.5 h, b) RT, 0.5 h
2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT
3: conc. hydrochloric acid / aq. ethanol / 0.5 h / Ambient temperature
4: 37 percent / p-toluenesulfonic acid, acetic acid / 24 h / Heating
View Scheme
参考文献
Katritzky, Alan R.; Lan, Xiangfu; Zhang, Zhongxing
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 2 p. 381 - 387
反应条件
1: conc. hydrochloric acid / aq. ethanol / 0.5 h / Ambient temperature
2: 37 percent / p-toluenesulfonic acid, acetic acid / 24 h / Heating
View Scheme
参考文献
Katritzky, Alan R.; Lan, Xiangfu; Zhang, Zhongxing
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 2 p. 381 - 387
反应条件
1: 66 percent / tBuOK / liquid ammonia / -33 °C / Irradiation
2: 1) ClSiMe3, NaI
View Scheme
参考文献
Beugelmans, Rene; Ginsburg, Helene
Journal of the Chemical Society, Chemical Communications, 1980 , # 11 p. 508 - 509
反应条件
1: 66 percent / tBuOK / liquid ammonia / -33 °C / Irradiation
2: 1) ClSiMe3, NaI
View Scheme
参考文献
Beugelmans, Rene; Ginsburg, Helene
Journal of the Chemical Society, Chemical Communications, 1980 , # 11 p. 508 - 509
反应条件
1: 1.) n-butyl lithium / 1.) hexane, 30 min, r.t.; 2.) hexane, 18 h, reflux
2: 72 percent / lithium iodide / various solvent(s) / 18 h / Heating
View Scheme
参考文献
Buckle, Derek, R.; Rockell, Caroline J. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2443 - 2446
反应条件
chromium dichloride; diethyl ether; boron trifluoride
1.) THF, 5 h; 2.) THF, reflux; Yield given. Multistep reaction;
参考文献
Ledoussal, B.; Gorgues, A.; Coq, A. Le
Tetrahedron, 1987 , vol. 43, # 43 p. 5841 - 5852
