2,3,5,6-四氟吡啶合成路线 （共 61 条）
反应条件
catalyst: Pd on active carbon in gaseous matrix C5F5N is heated to 180 °C (2 h) in H2 stream and the mixture is passed over catalyst (10 percent Pd/90 percent active carbon) at 300 °C.;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
[N-butylthiazolium][Br]; zinc in water T=70°C; 7 h;
参考文献
Prikhod'ko, Sergey A.; Adonin, Nicolay Yu.; Parmon, Valentin N.
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2265 - 2268
反应条件
ammonium hydroxide; zinc 5 h; Ambient temperature;
参考文献
Laev, Sergey S.; Shteingarts, Vitalij D.
Tetrahedron Letters, 1997 , vol. 38, # 21 p. 3765 - 3768
反应条件
NiCl2*2Phen; [N-butylthiazolium][Br]; zinc in water T=70°C; 7 h;
参考文献
Prikhod'ko, Sergey A.; Adonin, Nicolay Yu.; Parmon, Valentin N.
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2265 - 2268
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; 28 h; Title compound not separated from byproducts;
参考文献
Chambers, Richard D.; Hall, Christopher W.; Hutchinson, John; Millar, Ross W.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1705 - 1713
反应条件
tri-tert-butyl phosphine; trans-(tetrafluoropyrid-2-yl)bis(triethylphosphine)fluoronickel(II); caesium carbonate in tetrahydrofuran T=50°C; Product distribution;
参考文献
Brawn, Thomas; Perutz, Robin N.; Sladek, Marianna I.
Chemical Communications (Cambridge, United Kingdom), 2001 , # 21 p. 2254 - 2255
反应条件
1: 2,3,4,5,6-pentafluoropyridine With tin(ll) chloride; zinc in N,N-dimethyl-formamide 2: N,N-dimethyl-formamide With benzoyl chloride T=60 - 65°C; 4 h; Further stages;
参考文献
Vinogradov, Andrei S.; Krasnov, Vyacheslav I.; Platonov, Vyacheslav E.
Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 12 p. 1623 - 1630
反应条件
NiCl2*3Bpy; [N-butylthiazolium][Br]; zinc in water T=70°C; 7 h;
参考文献
Prikhod'ko, Sergey A.; Adonin, Nicolay Yu.; Parmon, Valentin N.
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2265 - 2268
反应条件
1: neat (no solvent) 2: diethyl ether View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
t-Bu-XantPhos; tBuXantphosAu(AuCl2); (Ph)2SiH2; acetic acid in 1,2-dichloro-ethane T=80°C; 24 h; Inert atmosphere;
参考文献
Zhan, Jin-Hui; Lv, Hongbin; Yu, Yi; Zhang, Jun-Long
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1529 - 1541
