2-苯并噻唑-2-氧基乙酸合成路线 （共 3 条）
反应条件
sodium hydroxide in methanol
20 h;
参考文献
Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701
反应条件
1: With potassium carbonate in acetone
15 h; Heating / reflux;
2: With sodium hydroxide in 1,4-dioxane; water
T=20°C;
3: With hydrogenchloride in 1,4-dioxane; water
参考文献
California Pacific Medical Center
Patent: US6350756 B1, 2002 ;
Location in patent: Page column 47-48 ;
反应条件
1: 89 percent / NaH / tetrahydrofuran / 1 h / Heating
2: 95 percent / aq. NaOH / methanol / 20 h
View Scheme
参考文献
Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701
