2-氯-1-(1H-吲哚-3-基)-乙酮合成路线 （共 18 条）
反应条件
in N,N-dimethyl-formamide T=100 - 110°C; 3 h;
参考文献
Povalyaeva, O. S.; Kurkovskaya, L. N.; Vigdorchik, M. M.; Suvorov, N. N.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 6 p. 1171 - 1179
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 6 p. 1294 - 1304
参考文献
Pedras, M. Soledade C.; Abdoli, Abbas
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4541 - 4549
反应条件
1: 80.5 percent / dioxane / 2 h / Heating
2: 95 percent / 10percent aq.K2CO3 / methanol
View Scheme
参考文献
Yagodinets, P. I.; Chernyuk, I. N.; Volynskaya, E. M.; Shevchuk, M. I.; Kushnir, V. N.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 4 p. 772 - 775,685 - 687
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
12 h;
参考文献
Johnson, Ann-Louise; Bergman, Jan
Tetrahedron, 2006 , vol. 62, # 47 p. 10815 - 10820
反应条件
1: NaN3 / acetone; H2O / Heating
2: 82 percent / K2CO3 / acetone / 16 h / Heating
View Scheme
参考文献
Moody, Christopher J.; Ward, John G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 12 p. 2903 - 2909
反应条件
1: benzene
2: LiAlH4
View Scheme
参考文献
Upjohn Co.
Patent: US2814625 , 1954 ;
反应条件
1: 71 percent / KBr / dimethylformamide / 24 h / 60 °C
2: 96 percent / NaBH4 / aq. ethanol / 20 h / 14 - 20 °C
3: 94 percent / 0.02N HCl / H2O / 1 h / 25 °C
4: 94 percent / H2, HClO4 / 10percent Pd-C / ethanol; H2O / 1 h / 17 °C / 760 Torr
View Scheme
参考文献
Fujii; Yoshifuji; Ito
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3348 - 3353
反应条件
1: 98 percent / NaN3 / acetone; H2O / Heating
2: H2; HCl / Pd/C / methanol
View Scheme
参考文献
Jiang, Biao; Gu, Xiao-Hui
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 2 p. 363 - 371
