1-萘-1-基丙-1-酮合成路线 （共 32 条）
反应条件
[{(η5-C5Me5)IrCl}2(μ-Cl)2]; SelectF in tetrahydrofuran
T=25°C; pH=7; 16 h; aq. phosphate buffer; regiospecific reaction;
参考文献
Ahlsten, Nanna; Bartoszewicz, Agnieszka; Agrawal, Santosh; Martin-Matute, Belen
Synthesis, 2011 , # 16 art. no. C57411SS, p. 2600 - 2608
反应条件
pyridinium chlorochromate in dichloromethane
1.5 h; Ambient temperature;
参考文献
Matsumoto; Ishida; Takeda; Soh; Kubo; Sakamoto
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 2 p. 216 - 222
反应条件
[NiI2(PPh3)]; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=80°C; Kumada Cross-Coupling; Inert atmosphere;
参考文献
Wu, Ji-Cheng; Gong, Lu-Bing; Xia, Yuanzhi; Song, Ren-Jie; Xie, Ye-Xiang; Li, Jin-Heng
Angewandte Chemie - International Edition, 2012 , vol. 51, # 39 p. 9909 - 9913
反应条件
Eu(2,2,6,6-tetramethyl-3,5-heptanedionate)3 in hexane; benzene
T=25°C; 24 h;
参考文献
Tsvelikhovsky, Dmitry; Gelman, Dmitri; Molander, Gary A.; Blum, Jochanan
Organic Letters, 2004 , vol. 6, # 12 p. 1995 - 1997
反应条件
1: 1,3-bis(diphenylphosphino)propane / Pd(OAc)2 / dimethylformamide / 2 h / 100 °C
2: H+
View Scheme
参考文献
Cabri, Walter; Candiani, Ilaria; Bedeschi, Angelo; Penco, Sergio; Santi, Roberto
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1481 - 1486
反应条件
(η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate in tetrahydrofuran; toluene
T=40°C; Mannich type reaction; 15 h; Inert atmosphereMolecular sieve; optical yield given as percent dediastereoselective reaction;
参考文献
Bartoszewicz, Agnieszka; Jezowska, Martina M.; Laymand, Kevin; Moebus, Juri; Martin-Matute, Belen
European Journal of Inorganic Chemistry, 2012 , # 9 p. 1517 - 1530
反应条件
[RuCl2(.eta.6-mesitylene)((R)-PhOP(binaphthoxy))]; potassium tert-butylate in tetrahydrofuran
T=75°C; 2.5 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Fernandez-Zumel, Mariano A.; Lastra-Barreira, Beatriz; Scheele, Marcus; Diez, Josefina; Crochet, Pascale; Gimeno, Jose
Dalton Transactions, 2010 , vol. 39, # 33 p. 7780 - 7785
参考文献
Marquet,A.; Jacques,J.
Bulletin de la Societe Chimique de France, 1960 , p. 166 - 169
Full Text Show Details
Blicke; Maxwell
Journal of the American Chemical Society, 1939 , vol. 61, p. 1780
反应条件
1: n-butyllithium
2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux
View Scheme
参考文献
Hu, Bin; Meng, Meng; Jiang, Shanshan; Deng, Weiping
Chinese Journal of Chemistry, 2012 , vol. 30, # 6 p. 1289 - 1294
反应条件
1: tetrahydrofuran / 14 h / 20 °C / |Inert atmosphere
2: hydrogenchloride / water / 8 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Baez-Santos, Yahira M.; Barraza, Scott J.; Wilson, Michael W.; Agius, Michael P.; Mielech, Anna M.; Davis, Nicole M.; Baker, Susan C.; Larsen, Scott D.; Mesecar, Andrew D.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2393 - 2412
