(2S)-羟基(苯基)乙酸 (1S)-3-(二甲基氨基)-1-(2-噻吩基)丙-1-醇盐合成路线 (共 2 条)
反应条件
sodium hydroxide in tert-butyl methyl ether; water T=20°C; pH=9; 0.5 h;
参考文献
USV LIMITED
Patent: WO2008/93360 A2, 2008 ;
Location in patent: Page/Page column 9-13 ;
反应条件
1: sodium hydroxide / water 2: sodium hydrogencarbonate / toluene / 90 °C 3: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 4: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913