6-乙酰基-1,4-苯并二氧杂环合成路线 （共 16 条）
反应条件
1: With morpholine; sulfur T=140°C; 14 h; 2: With potassium hydroxide in water 12 h; Reflux; 3: With hydrogenchloride in water pH=2;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
Location in patent: Page/Page column 113-114 ;
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
参考文献
Bourlot, Anne-Sophie; Sanchez, Isabel; Dureng, Georges; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Winslow, Eileen; Pujol, M. Dolors; Merour, Jean-Yves
Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3142 - 3158
反应条件
1: I2 / 20 - 100 °C
2: pyridine / Ambient temperature
3: aq. sodium hydroxide / 40 °C
View Scheme
参考文献
Hargrave, Karl D.; Hess, Friedrich K.; Oliver, James T.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1158 - 1163
反应条件
1: 95 percent / LiAlH4 / diethyl ether / 4 h / 35 °C
2: 52 percent / K2S2O7 / 0.5 h / 65 °C
View Scheme
参考文献
Mochalov, S. S.; Kosynkin, D. V.; Yudin, I. D.; Zavodskikh, K. A.; Shabarov, Yu. S.; Zefirov, N. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 4 p. 413 - 419
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 4 p. 472 - 479
反应条件
1: 60 percent / tetrahydrofuran / 20 h / 40 °C
2: 36 percent / conc. H2SO4 / benzene / Heating
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参考文献
Mochalov, S. S.; Kosynkin, D. V.; Yudin, I. D.; Zavodskikh, K. A.; Shabarov, Yu. S.; Zefirov, N. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 4 p. 413 - 419
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 4 p. 472 - 479
反应条件
1: alkaline aqueous sodium hypochlorite solution
2: acetic acid; sulfuric acid; nitric acid
3: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Heertjes et al.
Journal of the Chemical Society, 1957 , p. 3445
