4-溴-1-甲基-1H-吡唑-3-甲腈合成路线 （共 5 条）
反应条件
1: 4-bromo-1h-pyrazole-3-carbonitrile With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 1 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 1 h;
参考文献
WO2005/40110 A1, ;
Page/Page column 82 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide T=0°C;
参考文献
US2011/281888 A1, ;
Page/Page column 43 ;
反应条件
1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonium chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C 2: N,N-dimethyl-formamide; thionyl chloride / 0 °C View Scheme
反应条件
1: With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate in methanol
T=120°C; P=7500.75 Torr;
2: With water; sodium hydroxide in tetrahydrofuran; methanol
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEIMANN, Annekatrin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen
Patent: WO2014/56771 A1, 2014 ;
Location in patent: Page/Page column 98; 99 ;
反应条件
1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate / methanol / 120 °C / 7500.75 Torr
2: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C
View Scheme
参考文献
Boehringer Ingelheim International GmbH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen
Patent: US2014/100211 A1, 2014 ;
