4-[4-(三氟甲基)苯氧基]-1-哌啶羧酸 1,1-二甲基乙酯合成路线 （共 4 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=120°C; 48 h;
参考文献
E. Barta, Thomas; P. Becker, Daniel; J. Bedell, Louis; A. De Crescenzo, Gary; J. McDonald, Joseph; E. Munie, Grace; Rao, Shashi; Shieh, Huey-Sheng; Stegeman, Roderick; M. Stevens, Anna; I. Villamil, Clara
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2815 - 2817
反应条件
1: 89 percent / tetrahydrofuran / 0 °C 2: 81 percent / Cs2CO3 / dimethylformamide / 48 h / 120 °C View Scheme
参考文献
E. Barta, Thomas; P. Becker, Daniel; J. Bedell, Louis; A. De Crescenzo, Gary; J. McDonald, Joseph; E. Munie, Grace; Rao, Shashi; Shieh, Huey-Sheng; Stegeman, Roderick; M. Stevens, Anna; I. Villamil, Clara
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2815 - 2817
反应条件
1: 89 percent / tetrahydrofuran / 0 °C 2: 81 percent / Cs2CO3 / dimethylformamide / 48 h / 120 °C View Scheme
参考文献
E. Barta, Thomas; P. Becker, Daniel; J. Bedell, Louis; A. De Crescenzo, Gary; J. McDonald, Joseph; E. Munie, Grace; Rao, Shashi; Shieh, Huey-Sheng; Stegeman, Roderick; M. Stevens, Anna; I. Villamil, Clara
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2815 - 2817
反应条件
in 1,4-dioxane; diethyl ether
参考文献
G. D. Searle and Company
Patent: US6372758 B1, 2002 ;
US 6372758 B1
