4-(4-(三氟甲氧基)苯氧基)哌啶-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
potassium carbonate; tetrabutyl-ammonium chloride in water T=20 - 101°C; Heating / reflux;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2005/92832 A1, 2005 ;
Location in patent: Page/Page column 44-46 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran; water T=20°C;
参考文献
Shanghai Sun-Sail Pharmaceutical Science and Technology Co., Ltd; WANG, Tiancai; XIN, Ting; FAN, Houxing; CHEN, Yilang
Patent: EP2573090 A1, 2013 ;
Location in patent: Paragraph 0050-0052 ;
反应条件
1: 89 percent / tetrahydrofuran / 0 °C 2: NaH / 1-methyl-pyrrolidin-2-one / Heating View Scheme
参考文献
E. Barta, Thomas; P. Becker, Daniel; J. Bedell, Louis; A. De Crescenzo, Gary; J. McDonald, Joseph; E. Munie, Grace; Rao, Shashi; Shieh, Huey-Sheng; Stegeman, Roderick; M. Stevens, Anna; I. Villamil, Clara
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2815 - 2817
反应条件
1: 89 percent / tetrahydrofuran / 0 °C 2: NaH / 1-methyl-pyrrolidin-2-one / Heating View Scheme
参考文献
E. Barta, Thomas; P. Becker, Daniel; J. Bedell, Louis; A. De Crescenzo, Gary; J. McDonald, Joseph; E. Munie, Grace; Rao, Shashi; Shieh, Huey-Sheng; Stegeman, Roderick; M. Stevens, Anna; I. Villamil, Clara
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2815 - 2817
反应条件
sodium hydride in 1-methyl-pyrrolidin-2-one Heating;
参考文献
E. Barta, Thomas; P. Becker, Daniel; J. Bedell, Louis; A. De Crescenzo, Gary; J. McDonald, Joseph; E. Munie, Grace; Rao, Shashi; Shieh, Huey-Sheng; Stegeman, Roderick; M. Stevens, Anna; I. Villamil, Clara
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2815 - 2817
反应条件
hydrogenchloride in water
参考文献
G. D. Searle and Company
Patent: US6372758 B1, 2002 ;
US 6372758 B1
