5,11-二氢-11-氯乙酰基-6H-吡啶并[2.3-b][1,4]苯并二氮卓-6-酮合成路线 （共 18 条）
反应条件
triethylamine in 1,4-dioxane 8 h; Heating;
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 80 percent / 0.08 h / 205 °C 2: 70 percent / Et3N / dioxane / 8 h / Heating View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
1: acetonitrile / 3 h / Heating 2: 28 percent / acetic acid / 11 h / Heating 3: 5percentPd on active carbon / pyridine / 17 h / Heating 4: 53 percent / triethylamine / dioxane / 8 h / Heating View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
1: acetonitrile / 3 h / Heating 2: 28 percent / acetic acid / 11 h / Heating 3: 5percentPd on active carbon / pyridine / 17 h / Heating 4: 53 percent / triethylamine / dioxane / 8 h / Heating View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
1: 5percentPd on active carbon / pyridine / 17 h / Heating 2: 53 percent / triethylamine / dioxane / 8 h / Heating View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
1: 28 percent / acetic acid / 11 h / Heating 2: 5percentPd on active carbon / pyridine / 17 h / Heating 3: 53 percent / triethylamine / dioxane / 8 h / Heating View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
1: oxalyl chloride; DMF / tetrahydrofuran / 1 h / Heating 2: 5.55 g / pyridine / tetrahydrofuran / 2 h / 20 °C 3: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C 4: 80 percent / 0.08 h / 205 °C 5: 70 percent / Et3N / dioxane / 8 h / Heating View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C 2: 80 percent / 0.08 h / 205 °C 3: 70 percent / Et3N / dioxane / 8 h / Heating View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 5.55 g / pyridine / tetrahydrofuran / 2 h / 20 °C 2: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C 3: 80 percent / 0.08 h / 205 °C 4: 70 percent / Et3N / dioxane / 8 h / Heating View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
in N,N-dimethyl-formamide 36 h; Ambient temperature;
参考文献
Minarini, Anna; Bolognesi, Maria L.; Budriesi, Roberta; Canossa, Marco; Chiarini, Alberto; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3363 - 3372
