5,11-二氢-11-氯乙酰基-6H-吡啶并[2.3-b][1,4]苯并二氮卓-6-酮合成路线 (共 18 条)
反应条件
in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Minarini, Anna; Bolognesi, Maria L.; Budriesi, Roberta; Canossa, Marco; Chiarini, Alberto; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3363 - 3372
反应条件
sodium carbonate in acetonitrile 5 h; Heating;
参考文献
Engel, Wolfhard W.; Eberlein, Wolfgang G.; Mihm, Gerhard; Hammer, Rudolf; Trummlitz, Guenter
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1718 - 1724
反应条件
sodium carbonate in propan-1-ol; water; carbon; acetonitrile
参考文献
Dr. Karl Thomae GmbH
Patent: US4550107 A1, 1985 ;
US 4550107 A
反应条件
in benzene 18 h; Heating; Further byproducts given. Yields of byproduct given;
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
sodium carbonate in ethanol; carbon
参考文献
Boehringer Ingelheim GmbH
Patent: US4213984 A1, 1980 ;
反应条件
potassium carbonate in ethanol
参考文献
Boehringer Ingelheim GmbH
Patent: US4213984 A1, 1980 ;
反应条件
hydrogenchloride; sodium carbonate in ethanol
参考文献
Boehringer Ingelheim GmbH
Patent: US4213984 A1, 1980 ;
反应条件
in benzene
1.5 h; Heating;
参考文献
Decorte; Gratton; Kovac; Mihalic; Comisso; Angeli; Toso; Sunjic
Farmaco, Edizione Scientifica, 1982 , vol. 37, # 12 p. 787 - 796