1-苄基-4-(羟基甲基)-1H-1,2,3-噻唑合成路线 （共 15 条）
反应条件
Cu; triethylamine in benzene-d6 T=40°C; Huisgen Cycloaddition; 66 h; Inert atmosphere; regioselective reaction;
参考文献
Tahir, Muhammad Nazir; Qamar, Riaz-Ul; Mischnick, Petra; Kim, Jaebum; Jung, Seunho
Letters in Organic Chemistry, 2013 , vol. 10, # 4 p. 269 - 276
反应条件
sodium azide; L-ascorbic acid sodium salt in water; tert-butyl alcohol T=50°C; 2.5 h;
参考文献
Yamada, Yoichi M. A.; Sarkar, Shaheen M.; Uozumi, Yasuhiro
Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9285 - 9290
反应条件
sodium azide in water T=80°C; 0.133333 h; Microwave irradiationGreen chemistry; regioselective reaction;
参考文献
Xiong, Xingquan; Chen, Huixin; Tang, Zhongke; Jiang, Yunbing
RSC Advances, 2014 , vol. 4, # 19 p. 9830 - 9837
反应条件
CuF2 in methanol T=120°C; 0.333333 h; Microwave irradiation;
参考文献
Friscourt, Frederic; Boons, Geert-Jan
Organic Letters, 2010 , vol. 12, # 21 p. 4936 - 4939
反应条件
Cu2(OH)3OAc*H2O in acetonitrile T=100°C; 0.166667 h; Microwave irradiation;
参考文献
Buckley, Benjamin R.; Dann, Sandra E.; Harris, Daniel P.; Heaney, Harry; Stubbs, Emma C.
Chemical Communications, 2010 , vol. 46, # 13 p. 2274 - 2276
反应条件
1: With n-butyllithium; [HEMIM][OTf]; ferrous acetate in tetrahydrofuran T=65°C; 1 h; Inert atmosphere; 2: With water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 2 h; Inert atmosphere;
参考文献
Buitrago, Elina; Tinnis, Fredrik; Adolfsson, Hans
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 1 p. 217 - 222
反应条件
sodium azide in N,N-dimethyl-formamide T=110 - 120°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Maksikova, A. V.; Serebryakova, E. S.; Tikhonova, L. G.; Vereshchagin, L. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 12 p. 1284 - 1285
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 12 p. 1688 - 1689
反应条件
sodium azide in N,N-dimethyl-formamide T=110 - 120°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Maksikova, A. V.; Serebryakova, E. S.; Tikhonova, L. G.; Vereshchagin, L. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980 , vol. 16, # 12 p. 1284 - 1285
Khimiya Geterotsiklicheskikh Soedinenii, 1980 , vol. 16, # 12 p. 1688 - 1689
反应条件
1: sodium azide; potassium iodide / acetone; water / |Reflux 2: triphenylphosphine; copper (II) acetate monohydrate / dichloromethane / 20 °C View Scheme
参考文献
Neumajer, Gabor; Toth, Gergo; Beni, Szabolcs; Noszal, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 115 - 125
反应条件
in 1,4-dioxane reflux 4-7 h; Title compound not separated from byproducts;
参考文献
Megia-Fernandez, Alicia; Ortega-Munoz, Mariano; Lopez-Jaramillo, Javier; Hernandez-Mateo, Fernando; Santoyo-Gonzalez, Francisco
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3306 - 3320
