1,2-二氢-6-羟基-1-(2-羟基乙基)-4-甲基-2-氧代烟腈合成路线 （共 5 条）
反应条件
silica gel 0.0333333 h; microwave irradiation;
参考文献
Balalaie, Saeed; Kowsari, Elahe; Hashtroudi, Mehri S.
Monatshefte fur Chemie, 2003 , vol. 134, # 3 p. 453 - 456
反应条件
hydrogenchloride 0.333333 h; Heatingor 25percent aq. sodium hydroxide, reflux;
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
反应条件
hydrogenchloride; potassium hydroxide 1) methanol, reflux, 6h, 2) ethanol; Yield given. Multistep reaction;
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
反应条件
T=180°C; P=50 Torr; 3 h; o-dichlorobenzene, Dean-Stark;
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
反应条件
1: 15 g / 3 h / 180 °C / 50 Torr / o-dichlorobenzene, Dean-Stark
2: 1.4 g / 96percent sulphuric acid / 1 h / 80 °C
View Scheme
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
