1H-1,2,3-三氮唑合成路线 （共 105 条）
反应条件
potassium carbonate in ethanol
T=20°C;
参考文献
PFIZER LIMITED
Patent: WO2006/123242 A1, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/123242 A1
反应条件
potassium carbonate in ethanol
T=20°C;
参考文献
PFIZER LIMITED
Patent: WO2006/114706 A1, 2006 ;
Location in patent: Page/Page column 50 ;
WO 2006/114706 A1
反应条件
potassium carbonate in acetone
T=56°C; Reflux;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/95394 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
WO 2009/095394 A1
反应条件
sodium hydroxide; sodium iodide in 1,1-dimethylpropan-1-ol; toluene
参考文献
Ikemoto, Tomomi; Ito, Tatsuya; Tomimatsu, Kiminori; Sawai, Yasuhiro; Nishiyama, Hirohiko; Isogami, Yasushi
Patent: US2003/69419 A1, 2003 ;
反应条件
potassium carbonate; potassium iodide in acetone
Inert atmosphereReflux;
参考文献
Doiron, Jeremie; Soultan, Al Haliffa; Richard, Ryan; Toure, Mamadou Mansour; Picot, Nadia; Richard, Remi; Cuperlovic-Culf, Miroslava; Robichaud, Gilles A.; Touaibia, Mohamed
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4010 - 4024
反应条件
sodium hydride
1.) acetonitrile, 0 deg C, 24 h, 2.) methanol, a) from -25 to 20 deg C, 1 h, b) 20 deg C, 72 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Begtrup, Mikael; Larsen, Peter
Acta Chemica Scandinavica, 1990 , vol. 44, # 10 p. 1050 - 1057
反应条件
potassium carbonate; hydroxylamine-o-sulphonic acid in ethanol; water
参考文献
Dae Woong Pharmaceutical Co., Ltd.
Patent: US5336673 A1, 1994 ;
反应条件
potassium hydroxide; sodium hydroxylamine-O-sulfonate
T=55 - 60°C; 0.5 h;
参考文献
Kuz'menko, V. V.; Pozharskii, A. F.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 6.2 p. 1042
Zhurnal Organicheskoi Khimii, 1993 , vol. 28, # 6 p. 1320 - 1321
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=90 - 95°C; 4 h;
参考文献
Gareev, G. A.; Kirillova, L. P.; Belousov, A. M.; Bukina, N. S.; Vereshchagin, L. I.
Journal of Organic Chemistry USSR (English Translation), 1980 , p. 1494 - 1498
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 8 p. 1751 - 1755
反应条件
potassium phosphate; copper(l) iodide; ethylenediamine in 1,4-dioxane; dimethyl sulfoxide
72 h; Reflux;
参考文献
PORTOLA PHARMACEUTICALS, INC.; JIA, Zhaozhong J.; KANE, Brian; XU, Qing; BAUER, Shawn M.; SONG, Yonghong; PANDEY, Anjali; DICK, Ryan
Patent: WO2013/78468 A1, 2013 ;
Location in patent: Paragraph 0314; 0315 ;
