1H-1,2,3-三氮唑合成路线 （共 105 条）
反应条件
thionyl chloride; triethylamine
参考文献
Harada, Katsumasa; Oda, Mizuho; Matsushita, Akio; Shirai, Masashi
Synlett, 1998 , # 4 p. 431 - 433
参考文献
Bladin
Chemische Berichte, 1893 , vol. 26, p. 2737
反应条件
1: With caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide in N,N-dimethyl-formamide T=100°C; 0.166667 h; Microwave ready vessel; 2: in water Acidic conditions;
参考文献
WO2011/50200 A1, ;
Page/Page column 53; 79 ;
WO 2011/050200 A1
反应条件
caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide in N,N-dimethyl-formamide T=120°C; 0.166667 h; Microwave irradiation;
参考文献
WO2008/143856 A1, ;
Page/Page column 30 ;
WO 2008/143856 A1
反应条件
copper(l) iodide; caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine in N,N-dimethyl-formamide T=120°C; 0.166667 h; Microwave irradiation;
参考文献
WO2008/8518 A1, ;
Page/Page column 33-34 ;
WO 2008/008518 A1
反应条件
potassium carbonate in pyridine; hexane; ethyl acetate
参考文献
Japat Ltd.
Patent: US5703106 A1, 1997 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=120°C; 1 h;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
pyridine in dichloromethane; 1-chloro-1,1-difluoro-methane
参考文献
Bristol-Myers Company
Patent: US4714760 A1, 1987 ;
Title/Abstract Full Text Show Details
Bristol-Myers Company
Patent: US4868294 A1, 1989 ;
反应条件
potassium carbonate in sulfolane T=140°C; Condensation; 15 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117
反应条件
potassium carbonate in N,N-dimethyl-formamide T=70 - 80°C;
参考文献
MERCK CANADA INC.; BOYD, Michael John; CHIASSON, Jean-François; CRANE, Sheldon; GIROUX, André
Patent: WO2013/59928 A1, 2013 ;
Location in patent: Page/Page column 33-34 ;
