1H-1,2,3-三氮唑合成路线 （共 105 条）
参考文献
Hoffmann-La Roche Inc.
Patent: US4387100 A1, 1983 ;
US 4387100 A
反应条件
sodium hydride
1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide
T=20°C; 16 h; Product distribution / selectivity;
参考文献
Hadd, Mark Allen; Nichelson, Brian Joseph; Zhu, Zhijian
Patent: US2004/266848 A1, 2004 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium 1,2,3-triazolate in dimethyl sulfoxide
T=20°C; 16 h; Product distribution / selectivity;
参考文献
Hadd, Mark Allen; Nichelson, Brian Joseph; Zhu, Zhijian
Patent: US2004/266848 A1, 2004 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium 1,2,3-triazolate in chlorobenzene
T=20°C; 24 h; Product distribution / selectivity;
参考文献
Hadd, Mark Allen; Nichelson, Brian Joseph; Zhu, Zhijian
Patent: US2004/266848 A1, 2004 ;
Location in patent: Page/Page column 12 ;
反应条件
copper(l) iodide; caesium carbonate; Fe(acac)3 in N,N-dimethyl-formamide
T=120°C; Inert atmosphere;
参考文献
MSD OSS B.V.; HUISMAN, Ines; VAN DER STELT, Marcelis; WIEDENHOF, Wouter; BAKER-GLENN, Charles, Anthony, Graham; BLACKABY, Wesley, Peter; TRIVEDI, Naimisha
Patent: WO2013/41457 A1, 2013 ;
Location in patent: Page/Page column 41 ;
反应条件
sodium hydride
1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
in ethanol
T=80°C; 5 h;
参考文献
Vereshchagin, L. I.; Maksikova, A. V.; Tikhonova, L. G.; Buzilova, S. R.; Sakovich, G. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981 , vol. 17, # 5 p. 510 - 515
Khimiya Geterotsiklicheskikh Soedinenii, 1981 , # 5 p. 688 - 693
反应条件
in ethanol; water
Reflux;
参考文献
Kalisiak, Jaroslaw; Sharpless, K. Barry; Fokin, Valery V.
Organic Letters, 2008 , vol. 10, # 15 p. 3171 - 3174
反应条件
caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide in N,N-dimethyl-formamide
T=120°C; 0.166667 h; Microwave irradiation;
参考文献
GLAXO GROUP LIMITED; DI FABIO, Romano
Patent: WO2012/89606 A1, 2012 ;
Location in patent: Page/Page column 46 ;
WO 2012/089606 A1
