1: 1,3-thiazole With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 1 h;
2: 1,4-cyclohexanedione monoacetal in tetrahydrofuran; hexanes
T=-78°C; 3 h;
3: With water in tetrahydrofuran; hexanes
T=-78 - 20°C;
参考文献
PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
Location in patent: Page/Page column 46 ;
WO 2012/114223 A1
