3-(4-甲氧苯基)-3-氧代丙酸乙酯合成路线 （共 58 条）
反应条件
1: With sodium hydride in tetrahydrofuran Reflux; 2: With acetic acid in tetrahydrofuran
参考文献
Kumar, Satish; Namkung, Wan; Verkman; Sharma, Pawan K.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4237 - 4244
反应条件
1: 1-(4-methoxyphenyl)ethanone With sodium hydride in N,N-dimethyl-formamide T=10 - 25°C; 0.5 h; 2: carbonic acid diethyl ester in N,N-dimethyl-formamide T=10 - 25°C; 5 - 6 h;
参考文献
REDDY US THERAPEUTICS, INC.; KALLEDA, Srinivas; PADAKANTI, Srinivas; KUMAR SWAMY, Nalivela; YELESWARAPU, Koteswar, Rao; ALEXANDER, Christopher, W.; KHANNA, Ish, Kumar; IQBAL, Javed; PILLARISETTI, Sivaram; PAL, Manojit; BARANGE, Deepak
Patent: WO2006/34473 A2, 2006 ;
Location in patent: Page/Page column 193 ;
反应条件
1: in tetrahydrofuran T=0 - 25°C; 92 h; 2: With hydrogenchloride in tetrahydrofuran; water T=20 - 25°C; 1.58333 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1471056 A1, 2004 ;
Location in patent: Page 45 ;
反应条件
molybdenium(VI) dioxodichloride in dichloromethane T=20°C; 5 h;
参考文献
Jeyakumar, Kandasamy; Chand, Dillip Kumar
Synthesis, 2008 , # 11 p. 1685 - 1687
反应条件
acetic acid in water; toluene
参考文献
Dziki, Walter; Lu, Ziqi; Rasmussen, Michael W.; Wardrop, Jaqueline; Zhane, Geoff G.Z.; Linton, Cathie L.
Patent: US2006/63825 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
manganese(IV) oxide in dichloromethane T=20°C;
参考文献
Kafle, Bhooshan; Aher, Nilkanth G.; Khadka, Deegendra; Park, Hwangseo; Cho, Hyeongjin
Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 2073 - 2079
反应条件
lt;(η5-C5H5)Fe(CO)2(THF)gt;+lt;BF4gt;- in dichloromethane T=0°C; 8 h;
参考文献
Dudley, Matthew E.; Morshed, Monzur; Brennan, Courtney L.; Islam, M. Shahidul; Ahmad, M. Syarhabil; Atuu, Mary-Rose; Branstetter, Bryan; Hossain, M. Mahmun
Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7599 - 7608
反应条件
bis-triphenylphosphine-palladium(II) chloride in neat (no solvent) T=20°C; 2 h;
参考文献
Chen, Shufeng; Yuan, Fang; Zhao, Haiying; Li, Baoguo
RSC Advances, 2013 , vol. 3, # 31 p. 12616 - 12620
反应条件
aluminium trichloride in dichloromethane
参考文献
Kali-Chemie Pharma GmbH
Patent: US5474988 A1, 1995 ;
反应条件
sodium ethanolate T=0 - 5°C;
参考文献
Zhu, Youquan; Zou, Xiaomao; Hu, Fangzhong; Yao, Changsheng; Liu, Bin; Yang, Huazheng
Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 24 p. 9566 - 9570
