3-(4-甲氧苯基)-3-氧代丙酸乙酯合成路线 （共 58 条）
反应条件
1: 16 h 2: water; sodium carbonate / |Reflux View Scheme
参考文献
Wang, Teng; Jiao, Ning
Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 11692 - 11695
反应条件
1: 78 percent / DBU / tetrahydrofuran; propan-2-ol / 4 h / Ambient temperature 2: 12.34 g / H2 / Raney nickel / ethanol / 3040 Torr 3: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min 4: 2.775 g / C2H5ONa / ethanol / Heating 5: 91 percent / CH2Cl2 / 1 h / Ambient temperature 6: 95 percent / NaOH 7: 1.) Et3N, t-BuCOCl, 2.) n-BuLi 8: 4 N aq. HCl / dioxane 9: iPr2NEt / acetonitrile 10: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 5 p. 1039 - 1048
参考文献
Kulkarni et al.
Journal of Scientific and Industrial Research, 1958 , vol. 17A, p. 89
反应条件
sulfuric acid in ethanol
T=0 - 20°C; Pechmann condensation;
参考文献
Garazd; Ogorodniichuk; Khilya
Chemistry of Natural Compounds, 2002 , vol. 38, # 6 p. 539 - 548
反应条件
ytterbium trichloride in ethanol
T=50°C; 24 h;
参考文献
Cai, Lijian; Ji, Xiaofeng; Yao, Zhigang; Xu, Fan; Shen, Qi
Chinese Journal of Chemistry, 2011 , vol. 29, # 9 p. 1880 - 1886
反应条件
(i) NaH, THF, (ii) /BRN= 743112/, KI, acetone, (iii) KOH; Multistep reaction;
参考文献
Lawson,J.E. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 383 - 386
反应条件
1: With toluene-4-sulfonic acid in toluene
T=80°C; 16 h;
2: in diphenylether
3 h; Heating / reflux;
参考文献
WYETH
Patent: WO2004/103973 A1, 2004 ;
Location in patent: Page 18 ;
WO 2004/103973 A1
反应条件
1: p-TsOH / toluene / 80 °C
2: diphenyl ether / 200 °C
View Scheme
参考文献
Vu, An T.; Cohn, Stephen T.; Manas, Eric S.; Harris, Heather A.; Mewshaw, Richard E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4520 - 4525
反应条件
sodium tetrahydroborate in methanol
T=20°C; 3 h;
参考文献
Kim, Juryoung; De Castro, Kathlia A.; Lim, Minkyung; Rhee, Hakjune
Tetrahedron, 2010 , vol. 66, # 23 p. 3995 - 4001
反应条件
1: NH2OH*HCl / ethanol
2: 65 percent / acetic acid / 90 °C
View Scheme
参考文献
Rao; Reddy; Veeranagaiah
Synthesis, 1992 , # 5 p. 446 - 448
